Go Beyond Traditional Risk Factors

Recommended for Determining Future Health Risks

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Genetic risk assessments have come a long way over the years, but traditional risk assessments still focus almost exclusively on rare mutations in single genes, like

BRCA1/BRCA2 for breast cancer. Thanks to years of medical research and the development of big datasets, Polygenic Risk Scores can now be used to assess an individual’s genetic risk of common disease and to identify the cause of disease in the absence of other risk factors.

A Polygenic Risk Score (PRS) measures the component of disease risk from many genetic variants spread throughout the genome. Lifetime risk of disease is calculated by comparing the tested individual’s PRS to a reference population of the same ancestry.

Dynamic DNA’s clinical-grade PRS reports are backed by the latest science and have been developed to present concise, clear and actionable information on disease risk. By communicating both relative and absolute risk of disease together with recommendations on how to mitigate risk, Dynamic DNA’s reports empower physicians and patients by providing the essential context to genetic risk.

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AGE OF SCREENING:

PRS provides actionable information in the form of screening age recommendations. Every woman’s breast cancer risk increases with age. In the chart below, a woman with an average PRS is represented by the blue line, while the orange line is the tested individual. The screening threshold (red line) represents the 10 year risk that an average woman reaches at age 50 when mammography typically starts. In this example, the tested woman reaches the same risk about 24 years earlier.

Age of screening

RELATIVE AND ABSOLUTE RISK:

Clear, unambiguous results provide direct insights into an individual’s 5-year and lifetime risk of disease.

Polygenic Risk Screening

Polygenic Risk Scores

(PRS)