What is PGx ?
Pharmacogenetics (PGx) is a branch of Personalized Medicine that utilizes genetic analysis to determine how a patient will respond to different medications. This testing virtually eliminates the possibility of adverse drug reactions, reducing the trial-and-error approach to selecting an effective drug therapy. The goal is to decrease the risk of detrimental and often life-threatening side effects from prescription drug usage.
Our testing employs next-generation robotics combined with tried and true quantitative polymerase chain reaction (qPCR) technology, allowing us to target several clinically relevant and medically actionable Drug Metabolizing Enzymes (DMEs) simultaneously. All assays demonstrate an analytical sensitivity and specificity >99%.
Adults take at least one medication.
Deaths per year due to adverse drug effects.
Extra medical cost spent on adverse drug events annually.
Adults take five or more medications.
Pharmacogenetic Testing Panels
Nearly every individual will be prescribed an opioid-based pain reliever at some point in their life. Aside from the potential for addiction, there is the chance for unintentional overdose and death. There is perhaps no better application for PGx testing. We screen for over 30 different drugs used in the treatment of chronic or acute pain including, but not limited to:
- Opiates (i.e. Hydrocodone, Morphine, OxyContin, Tramadol)
- Steroids (i.e. Dexamethasone)
- Muscle Relaxers (i.e. Soma)
- NSAID (i.e. Celebrex, Ansaid)
Cardiovascular drugs are the most widely prescribed class of medication. Over 26 million adults are currently living with heart disease, the leading cause of death for men and women in the United States. We screen for over 25 cardiovascular medications including, but not limited to:
- Statins (i.e. Lipitor and Zocor)
- Anti-Coagulants (i.e. Plavix and Warfarin)
- Beta Blockers (i.e. Lopressor)
- Anti-Hypertensive (i.e. Coreg)
Mental health includes our emotional, psychological, and social well-being. Whether it be depression, anxiety or mood swings, nearly everyone is affected in one way or another. 1 in every 10 Americans take an antidepressant, and up to 38% of individuals report side-effects. We screen for over 30 psychotropic medications including, but not limited to:
- Anti-Depressants (i.e. Abilify, Prozac, Zoloft, Cymbalta)
- Anti-Psychotics (i.e. Seroquel)
- Anti-Anxiety (i.e. Xanax, Valium)
This option includes all three of the previous panels, plus additional medical insights for many other drug classes, totaling over 200 medications. Since your DNA never changes, these results will forever be a guide to you and your physician as your body and medical needs evolve. Additional areas covered include:
- Gastrointestinal disorders
- Infectious disease
Based upon the patient’s genotype, the medication can be prescribed according to standard regimens or the patient’s risk for the indicated condition is not increased.
Based upon the patient’s genotype, guidelines exist for adjusting dosage or increased vigilance, or the patient has a moderate risk for the indicated condition.
Based upon the patient’s genotype, a medication has potentially reduced efficacy or increased toxicity, or the patient has an increased risk for the indicated condition.